Here come my totally contrasting opinions:
1. I don't fully understand what is happening -- who is Mr. Depp?
2. Spontaneous combustion is a tired cliche, as evil_d said, with that prop. I'd like to see the fire prop used in some kind of fire safety/smokey the bear themed comic. Also, Asiangirl 2 is discussing the low risk of sexual side effects in the first panel, yet you list impotence as the first side effect of the drug. If this were a list of ingredients on a food package, impotence would be the main ingredient -- leading me to believe impotence is the most common side effect. THis causes inconsistence in the comic.
3. Good. Well thought out, Mr. Weed's "I wonder where I can get some weed in this town" took away from the comic, in my opinion. It did not add to it.
4. Second news reporter -- why is she talking? Creates inconsistence in the strip. Had she talked first, it would have been okay, then it would have led into the second panel. How did Priest & Jon end up in prison? I don't get the last panel there.
5. I have no idea what penguin was talking about at the end. I kind of chuckled at "You know penguins aren't bipolar" -- maybe it was just the character stating it.
6. Liked it. But narration called for some kind of food commercial where this was more of a story about a rich republican cat.
7. Good. Liked the ending. There was more talking than I was prepared for and it made me reread certain parts. That lost my interest.
---
Mediocrity at its most average.